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Supplements: Take Them or Leave Them?

  • August 28, 2023
  • Doctor Lawrence

Hello, My28Days community,

We recently received a question about supplements for women with Primary Ovarian Insufficiency (POI). Women with POI are at risk for osteoporosis and heart disease due to their deficiency in estradiol. If they become pregnant, they are also at risk of having a child with a congenital disability related to folic acid deficiency. Women with POI need to supplement with physiologic hormone replacement (P-HRT) to provide the required estradiol, like how the ovaries provide this hormone naturally. Balancing this estradiol replacement with a progestogen, such as medroxyprogesterone acetate, is essential.

Adequate calcium intake is also essential, preferably through dietary intake, and dietary intake is not enough, then a calcium supplement is needed. Vitamin D is also necessary to maintain healthy bones, and most women need to take a supplement of 800 IU of Vitamin D3 per day. To learn more about P-HRT, check out the featured post at the top of our Facebook page.

Lastly, we want to remind all women who are trying to become pregnant to consume 400 mcg of folic acid daily from supplements, fortified foods, or both, in addition to the folate they get from following a healthy eating pattern. This folic acid supplement is essential for women with POI who may become pregnant unexpectedly.

In health,

Doctor Lawrence logo

Dr. Lawrence M. Nelson, MD, MBA
Director, My 28 Days® Initiative
President, Mary Elizabeth Conover Foundation, Inc.

Menstrual and Ovarian Health

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