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Download Answers

If your period isn’t normal, it isn’t normal.


What is POI?

What are the signs, symptoms and treatments of primary ovarian insufficiency? Get answers here.


What is P-HRT?

Learn more about physiologic hormone replacement therapy and how it works here.


Questions to Ask Your Doctor

Chances are your doctor is not an expert in POI. Print this list of questions to help educate and advocate to get the answers and care you need.


My 28 Days.

Women know this as the interval between one menstrual cycle and the next. Girls and women, young and old, live by this rhythm throughout their lives. They track fertility, pregnancy, health issues, events — even what to wear and when. On one hand, they count the days to cramping and bleeding, ovulation and conception, due dates and not getting pregnant. On the other hand, they count the days to vacations, sporting events, and date nights.

Perhaps most significantly, they count the days to assure and reassure, to validate signs and symptoms, and even to forecast when the days of counting might be over for good. Yet, as we get caught up in this endless scheduling, it’s easy to lose sight of not only how a woman’s menstrual cycle is an important indicator of her health and well-being, but also how more than half of the world’s population is lacking the vital health care information needed to fully understand women and young girls’ menses.

My 28 Days is a comprehensive resource for information about estradiol across the lifespan. Find answers, ask questions, and learn more about menstrual and ovarian health so you can be an informed advocate for your own health and wellness.

“[When periods are regular] it’s the sign that the ovaries and the whole endocrine system related to reproduction is working the way it should.”

Dr. Lawrence Nelson,


Doctor Lawrence on NPR

Menstrual and Ovarian Health

Follow the Evidence

POI Fast Facts

POI is a hormonal deficiency. It is not menopause.

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Know Your Numbers

Understanding estradiol deficiency begins with understanding ovarian hormones.

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The Evidence

Research can help you make evidence-based decisions.

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Think Again

Educate and advocate. Your doctor may not be an expert.

Read More