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Evidence-based answers

These statements are intended only to provide information, not medical advice. Medical issues should be discussed with the responsible clinician who is prescribing the treatment. Treatment must be evaluated in the context of each individual’s specific situation. Following is information and evidence in medical literature. Anything read here should be discussed with an individual’s own health care team to determine if this evidence applies to your situation.

  • Published scientific evidence has demonstrated the most common problem preventing normal ovarian follicle function and ovulation in women with POI is inappropriate luteinization of growing follicles.
  • Published evidence has demonstrated the NIH P-HRT regimen suppresses serum LH levels to normal in women with POI. Published evidence has demonstrated you should be on the NIH P-HRT regimen to keep your bones healthy.
  • Theoretically, lowering the LH level in your blood should improve the chances of you ovulating by reducing the chances of the follicles becoming luteinized. This has not yet been proven by prospective study, however. As a group, women with POI should be advocating for more studies about how to improve their natural fertility.
Menstrual and Ovarian Health

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