Evidence-based answers
These statements are intended only to provide information, not medical advice. Medical issues should be discussed with the responsible clinician who is prescribing the treatment. Treatment must be evaluated in the context of each individual’s specific situation. Following is information and evidence in medical literature. Anything read here should be discussed with an individual’s own health care team to determine if this evidence applies to your situation.
- Published scientific evidence has demonstrated the most common problem preventing normal ovarian follicle function and ovulation in women with POI is inappropriate luteinization of growing follicles.
- Published evidence has demonstrated the NIH P-HRT regimen suppresses serum LH levels to normal in women with POI. Published evidence has demonstrated you should be on the NIH P-HRT regimen to keep your bones healthy.
- Theoretically, lowering the LH level in your blood should improve the chances of you ovulating by reducing the chances of the follicles becoming luteinized. This has not yet been proven by prospective study, however. As a group, women with POI should be advocating for more studies about how to improve their natural fertility.
It’s American Heart Month. What Does that Mean for Women?
Women’s Heart Health and Estradiol Deficiency When it comes to women’s health and hormones, it’s typical to think of sex hormone levels, periods, night sweats, bone loss, mood swings, and ev...
How do I prepare for a healthy pregnancy based on the best evidence?
Preconception health care focuses on the parts of health that have been shown to increase the chance of having a healthy baby. Because it differs from person to person depending on unique individual ...
How do women with POI who are trying to conceive (TTC) handle hormone replacement therapy (HRT)?
Here is a helpful set of steps to take: Discuss getting on the National Institutes of Health physiologic HRT regimen (NIH P-HRT). This will give you regular menstrual cycles so you will know to g...
How is P-HRT safer than the standard traditional HRT? And, what are the risks?
Women with POI are missing the main hormone messenger estradiol, which has the main function of maturing and then maintaining the reproductive system. During the menstrual cycle, increased estradiol ...
What is physiologic hormone replacement therapy (P-HRT)?
Physiologic hormone replacement therapy, or P-HRT, is just what it says — replacing hormones your body needs and is no longer producing in normal amounts. Because P-HRT restores the body’s estrad...
What are treatments for POI and/or associated estradiol deficiency?
Although there’s currently no known cure for POI, there are ways to reduce symptoms and stabilize a woman’s overall health. One way to do this is through physiologic hormone replacement therapy, ...
How do I find a provider willing to help me with POI?
At My 28 Days, we believe women with POI need accurate, credible information so they can take a proactive, preventive approach to menstrual health. It’s important to note the goal of preventive med...
What are some symptoms of primary ovarian insufficiency and estradiol deficiency?
One of the early symptoms of the onset of POI is irregular or missed periods. As the disorder progresses and the hormonal deficiency worsens, other symptoms that resemble menopause may appear, includ...
