Menopause Age Shaped by Genes that Influence Mutation Risk
By mining large-population genetic data sets, researchers identify the key factors controlling menopause timing, and reveal a close connection between reproductive longevity, cancer risk and new muta...
Premature Menopause May Increase Risk of Death from Heart Disease, Cancer
Researchers report that women who enter menopause before age 40 are twice as likely to die from heart disease and four times as likely to die from cancer. Experts say hormone replacement therapy ...
The Association Between Primary Ovarian Insufficiency and Increased Multimorbidity
The purpose of this study was to determine the association between age of menopause and multimorbidity in a large Canadian prospective cohort. It was hypothesized that participants with earlier age a...
Discovery of a Rare Genotype Causing Primary Ovarian Insufficiency
Scientists at deCODE genetics and collaborators, have identified a sequence variant in the CCDC201 gene that when inherited from both parents homozygous causes menopause on average nine years earlier...
Primary Ovarian Insufficiency Goes Undiagnosed in Teenagers.
At 19 years old, Vienna was diagnosed with Primary Ovarian insufficiency (POI) — a condition that affects 1% of women between 15-44. POI causes the ovaries to stop working normally before the age o...
Breast Cancer Is Increased in Women With Primary Ovarian Insufficiency
Primary ovarian insufficiency (POI) is defined as primary hypogonadism in women before the age of 40 years. Autoimmune causes, FMR1 premutations, and X chromosome deletions and translocations account...
The Primary Ovarian Insufficiency Readiness Initiative
Welcome to the POI Readiness Initiative, brought to you by the Mary Elizabeth Conover Foundation and William Brown Consulting, LLC. We designed this unique initiative to support women with Primar...
Metabolic Profiling in Plasma and Brain Induced by 17β-Estradiol Supplementation in Ovariectomized Mice
Estrogen deficiency is common in women during menopause and is associated with conditions such as osteoporosis, metabolic dysfunction, and neurological diseases. 17β-Estradiol, one of the primary es...
